Publications

  1. Poon, GMK. (2021) The Non-continuum Nature of Eukaryotic Transcriptional Regulation. Adv Exp Med Biol, :
  2. Poon, GM, Wong, KL, Chen, H, Saggi, SS, Lai, M, Wong, MK, Chan, D. (2020) Cervical Spine Fracture after a Bone Cracking Traditional (Tui Na) Massage. Ann Acad Med Singap, 49:915-918
  3. Afek, A, Shi, H, Rangadurai, A, Sahay, H, Senitzki, A, Xhani, S, Fang, M, Salinas, R, Mielko, Z, Pufall, MA, Poon, GMK, Haran, TE, Schumacher, MA, Al-Hashimi, HM, Gordân, R. (2020) DNA mismatches reveal conformational penalties in protein-DNA recognition. Nature, 587:291-296
  4. Ha, VLT, Erlitzki, N, Farahat, AA, Kumar, A, Boykin, DW, Poon, GMK. (2020) Dissecting Dynamic and Hydration Contributions to Sequence-Dependent DNA Minor Groove Recognition. Biophys J, 119:1402-1415
  5. Xhani, S, Lee, S, Kim, HM, Wang, S, Esaki, S, Ha, VLT, Khanezarrin, M, Fernandez, GL, Albrecht, AV, Aramini, JM, Germann, MW, Poon, GMK. (2020) Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1. Sci Adv, 6:eaay3178
  6. Liu, B, Bashkin, JK, Poon, GMK, Wang, S, Wang, S, Wilson, WD. (2019) Modulating DNA by polyamides to regulate transcription factor PU.1-DNA binding interactions. Biochimie, 167:1-11
  7. Vo, T, Albrecht, AV, Wilson, WD, Poon, GMK. (2019) Quantifying length-dependent DNA end-binding by nucleoproteins. Biophys Chem, 251:106177
  8. Huang, K, Xhani, S, Albrecht, AV, Ha, VLT, Esaki, S, Poon, GMK. (2019) Mechanism of cognate sequence discrimination by the ETS-family transcription factor ETS-1. J Biol Chem, 294:9666-9678
  9. Wohlfahrt, T, Rauber, S, Uebe, S, Luber, M, Soare, A, Ekici, A, Weber, S, Matei, AE, Chen, CW, Maier, C, Karouzakis, E, Kiener, HP, Pachera, E, Dees, C, Beyer, C, Daniel, C, Gelse, K, Kremer, AE, Naschberger, E, Stürzl, M, Butter, F, Sticherling, M, Finotto, S, Kreuter, A, Kaplan, MH, Jüngel, A, Gay, S, Nutt, SL, Boykin, DW, Poon, GMK, Distler, O, Schett, G, Distler, JHW, Ramming, A. (2019) PU.1 controls fibroblast polarization and tissue fibrosis. Nature, 566:344-349
  10. Erlitzki, N, Farahat, AA, Kumar, A, Boykin, DW, Poon, GMK. (2019) DNA recognition by linear indole-biphenyl DNA minor groove ligands. Biophys Chem, 245:6-16
  11. Albrecht, AV, Kim, HM, Poon, GMK. (2018) Mapping interfacial hydration in ETS-family transcription factor complexes with DNA: a chimeric approach. Nucleic Acids Res, 46:10577-10588
  12. Mao, P, Brown, AJ, Esaki, S, Lockwood, S, Poon, GMK, Smerdon, MJ, Roberts, SA, Wyrick, JJ. (2018) ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. Nat Commun, 9:2626
  13. Antony-Debré, I, Paul, A, Leite, J, Mitchell, K, Kim, HM, Carvajal, LA, Todorova, TI, Huang, K, Kumar, A, Farahat, AA, Bartholdy, B, Narayanagari, SR, Chen, J, Ambesi-Impiombato, A, Ferrando, AA, Mantzaris, I, Gavathiotis, E, Verma, A, Will, B, Boykin, DW, Wilson, WD, Poon, GM, Steidl, U. (2017) Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest, 127:4297-4313
  14. Esaki, S, Evich, MG, Erlitzki, N, Germann, MW, Poon, GMK. (2017) Multiple DNA-binding modes for the ETS family transcription factor PU.1. J Biol Chem, 292:16044-16054
  15. Vo, T, Wang, S, Poon, GMK, Wilson, WD. (2017) Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6. J Biol Chem, 292:13187-13196
  16. Erlitzki, N, Huang, K, Xhani, S, Farahat, AA, Kumar, A, Boykin, DW, Poon, GMK. (2017) Investigation of the electrostatic and hydration properties of DNA minor groove-binding by a heterocyclic diamidine by osmotic pressure. Biophys Chem, 231:95-104
  17. Poon, GMK, Kim, HM. (2017) Signatures of DNA target selectivity by ETS transcription factors. Transcription, 8:193-203
  18. Xhani, S, Esaki, S, Huang, K, Erlitzki, N, Poon, GM. (2017) Distinct Roles for Interfacial Hydration in Site-Specific DNA Recognition by ETS-Family Transcription Factors. J Phys Chem B, 121:2748-2758
  19. Stephens, DC, Poon, GM. (2016) Differential sensitivity to methylated DNA by ETS-family transcription factors is intrinsically encoded in their DNA-binding domains. Nucleic Acids Res, 44:8671-8681
  20. Stephens, DC, Kim, HM, Kumar, A, Farahat, AA, Boykin, DW, Poon, GM. (2016) Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res, 44:4005-13
  21. Wang, S, Poon, GM, Wilson, WD. (2015) Quantitative Investigation of Protein-Nucleic Acid Interactions by Biosensor Surface Plasmon Resonance. Methods Mol Biol, 1334:313-32
  22. He, G, Tolic, A, Bashkin, JK, Poon, GM. (2015) Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors. Nucleic Acids Res, 43:4322-31
  23. Giang, I, Boland, EL, Poon, GM. (2014) Prodrug applications for targeted cancer therapy. AAPS J, 16:899-913
  24. Wang, S, Linde, MH, Munde, M, Carvalho, VD, Wilson, WD, Poon, GM. (2014) Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1. J Biol Chem, 289:21605-16
  25. Boland, EL, Van Dyken, CM, Duckett, RM, McCluskey, AJ, Poon, GM. (2014) Structural complementation of the catalytic domain of pseudomonas exotoxin A. J Mol Biol, 426:645-55
  26. Munde, M, Wang, S, Kumar, A, Stephens, CE, Farahat, AA, Boykin, DW, Wilson, WD, Poon, GM. (2014) Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res, 42:1379-90
  27. Munde, M, Poon, GM, Wilson, WD. (2013) Probing the electrostatics and pharmacological modulation of sequence-specific binding by the DNA-binding domain of the ETS family transcription factor PU.1: a binding affinity and kinetics investigation. J Mol Biol, 425:1655-69
  28. Poon, GM. (2013) Quantitative analysis of affinity enhancement by noncovalently oligomeric ligands. Anal Biochem, 433:19-27
  29. Poon, GM. (2012) DNA binding regulates the self-association of the ETS domain of PU.1 in a sequence-dependent manner. Biochemistry, 51:4096-107
  30. Poon, GM. (2012) Sequence discrimination by DNA-binding domain of ETS family transcription factor PU.1 is linked to specific hydration of protein-DNA interface. J Biol Chem, 287:18297-307
  31. Poon, GM. (2010) Explicit formulation of titration models for isothermal titration calorimetry. Anal Biochem, 400:229-36
  32. McCluskey, AJ, Poon, GM, Bolewska-Pedyczak, E, Srikumar, T, Jeram, SM, Raught, B, Gariépy, J. (2008) The catalytic subunit of shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domain. J Mol Biol, 378:375-86
  33. Poon, GM. (2007) Enhancement of oligomeric stability by covalent linkage and its application to the human p53tet domain: thermodynamics and biological implications. Biochem Soc Trans, 35:1574-8
  34. McCluskey, AJ, Poon, GM, Gariépy, J. (2007) A rapid and universal tandem-purification strategy for recombinant proteins. Protein Sci, 16:2726-32
  35. Poon, GM, Gariépy, J. (2007) Cell-surface proteoglycans as molecular portals for cationic peptide and polymer entry into cells. Biochem Soc Trans, 35:788-93
  36. Poon, GM, Brokx, RD, Sung, M, Gariépy, J. (2007) Tandem dimerization of the human p53 tetramerization domain stabilizes a primary dimer intermediate and dramatically enhances its oligomeric stability. J Mol Biol, 365:1217-31
  37. Sung, M, Poon, GM, Gariépy, J. (2006) The importance of valency in enhancing the import and cell routing potential of protein transduction domain-containing molecules. Biochim Biophys Acta, 1758:355-63
  38. Poon, GM, Abu-Ghazalah, RM, Macgregor, RB Jr. (2004) Ionic mobilities of duplex and frayed wire DNA in discontinuous buffer electrophoresis: evidence of interactions with amino acids. Biochemistry, 43:16337-47
  39. Poon, GM, Macgregor, RB Jr. (2004) A thermodynamic basis of DNA sequence selectivity by the ETS domain of murine PU.1. J Mol Biol, 335:113-27
  40. Macgregor, RB, Poon, GM. (2003) The DNA double helix fifty years on. Comput Biol Chem, 27:461-7
  41. Poon, GM, Macgregor, RB Jr. (2003) Base coupling in sequence-specific site recognition by the ETS domain of murine PU.1. J Mol Biol, 328:805-19
  42. Poon, GM, Gross, P, Macgregor, RB Jr. (2002) The sequence-specific association of the ETS domain of murine PU.1 with DNA exhibits unusual energetics. Biochemistry, 41:2361-71
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