New publication in Biophysical Journal

Congratulations to Van for our first paper in the journal of the Biophysical Society. This work marks a major effort in our group to combine volumetric and molecular dynamics simulations to understand the role of solvent in the selectivity of DNA minor groove binding. Our model compound, DB1976, has been gaining increasing attention for its therapeutic potential as a PU.1 inhibitor in leukemia, rheumatologic, and obesity-related liver disorders. We are grateful, as always, to Dr. Dave Boykin and his fantastic synthetic group for making this unique compound available.

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